I can't find the study about this compound, Discovery and development of an oral analgesic targeting the α2B adrenoceptor, anywhere. I'd like to read more about the clinical pharmacology in detail.
A new class of selective α2B-adrenoceptor antagonist.
cluckindan 33 days ago [-]
Sounds like it comes with an increased risk of stroke and cardiological issues, psychomotor agitation, anxiety, aggression, possibly even psychosis. Humans have noradrenaline regulation for a reason.
tsol 33 days ago [-]
We'll have to see. There are a lot of natural and experimental painkillers that aren't used either because of side effects or more often because they just don't work consistently. It just so happens that so far the opioids are the only ones that can handle extreme pain. It's a hard problem to solve
elric 33 days ago [-]
Does the article not consider those to be serious side effects then? What is considered serious?
cluckindan 33 days ago [-]
In this case, I believe ”serious side effects” is referring to opioid addiction and physical dependency.
raylad 34 days ago [-]
It works by causing a release of noadrenalin.
Prediction: It will end up being used by the military and/or fighters to provide instantaneous muscle strength coupled with pain relief from overexertion.
harvie 34 days ago [-]
Isn't that just gonna keep the patients in constant fight-or-flight mode? Perhaps developing PTSD or something over time...
buran77 34 days ago [-]
With soldiers it makes sense to use it explicitly to enforce the "fight" mode as needed. This can range from "occasionally in emergencies" to "all the time".
But militaries have famously not cared about the long term health and well being of their forces past their active use. So any consequence of "long term fight mode" past victory day are just the cost of doing business.
xeonmc 33 days ago [-]
"Your injuries were not service related."
phatskat 33 days ago [-]
“Victory day” lol, I think the only one I’ve been alive for so far was “Mission Accomplished”
mvdtnz 34 days ago [-]
It's only constant if you constantly administer it
miningape 34 days ago [-]
Sounds like a secondary concern to me /s
FirmwareBurner 34 days ago [-]
Star Craft marine stim packs let's gooooo
binary132 33 days ago [-]
My exact first thought
tsoukase 33 days ago [-]
It is hard to beat morphine and its derivatives (eg fentanyl). In strict medical settings they are excellent analgetics and anxiolytics, safe with minor side effects. The only problem is when things go wary after the initial use (dependence etc).
M95D 33 days ago [-]
What about tolerance? Will it need increasing doses to be effective?
erickhill 34 days ago [-]
Why is this written in such a way to only target cancer patients?
bitwize 34 days ago [-]
The class of patients most likely to require opioids over long periods of time?
delusional 34 days ago [-]
And a class disproportionately insensitive to long term negative side effects.
briangriffinfan 33 days ago [-]
I have GOT to find a way to describe more things like this.
There's also the alternative Journavx: https://en.wikipedia.org/wiki/Suzetrigine
Prediction: It will end up being used by the military and/or fighters to provide instantaneous muscle strength coupled with pain relief from overexertion.
But militaries have famously not cared about the long term health and well being of their forces past their active use. So any consequence of "long term fight mode" past victory day are just the cost of doing business.